The most powerful toxins

Name

DL₅₀ [mg/kg]^a

Comments

Protein and peptide toxins

Toxin of botulin

0.00000003

protein, MW=9´10⁵ g/mol, blocks synapses

Toxin of tetanus

0.0000001

protein, MW=10⁵ g/mol

Toxin of difteria

0.0003

protein, MW=7.2´10⁵ g/mol

Cobrotoxin

0.0003

paralyses nervous system

Castor oil pomace

0.002^b

toxoalbumin removed during production process

a-Amanitin

0.1

hepatotoxin (destroys liver)

Bungarotoxin

0.15

protein toxin of viper venom

Phalloidin

2.0

hepatotoxin (destroys liver)

Melitine

4.0

destroys erythrocytes

 Nonprotein organic substances

Palytoxin

0.00015

allows sodium and potassium ions to leak through cell membranes of erythrocytes

Tetrachlorodioxin

0.001

mutagen

Tetrodotoxin

0.005

blocks ion transport through cell membranes

Saxitoxin

0.01

neurotoxin

Toxiferin C

0.025

currara`s component

Strychnine

0.5

paralyses nervous system

Muscarine

0.5

paralyses nervous system

Colchicine

3.0

causes diarrhoea, destroys blood producing system

Nicotine

16

paralyses breathing system

Coniine

60

paralyses muscles

Digitonine

150

acts on heart action

Solanine

200

paralyses muscles

 Inorganic substances

Soman

0.4

paralyses nervous system

Potassium cyanide

3.0

blocks some enzymes of responsible

for oxigen assimilation

Arsenic

10 ^c

blocks some enzymes containing thiol groups